Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease
Identifieur interne : 004A53 ( Main/Exploration ); précédent : 004A52; suivant : 004A54Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease
Auteurs : E. Loannidou [États-Unis] ; H. Swede [États-Unis] ; A. Dongari-Bagtzoglou [États-Unis]Source :
- Journal of dental research [ 0022-0345 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) ≥ 5 mm and (CAL) ≥ 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. CKD was defined based on eGFR < 60 mL/min/1.73m2 and albuminuria > 30 mg/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).
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Swede</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Epidemiology and Biostatistics, Department of Community Medicine and Health Care, University of Connecticut Health Center, 263 Farmington Ave</s1><s2>Farmington, CT 06030</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Dongari Bagtzoglou, A" sort="Dongari Bagtzoglou, A" uniqKey="Dongari Bagtzoglou A" first="A." last="Dongari-Bagtzoglou">A. 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Loannidou</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Periodontology, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, 263 Farmington Ave</s1><s2>Farmington, CT 06030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Swede, H" sort="Swede, H" uniqKey="Swede H" first="H." last="Swede">H. Swede</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Epidemiology and Biostatistics, Department of Community Medicine and Health Care, University of Connecticut Health Center, 263 Farmington Ave</s1><s2>Farmington, CT 06030</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Dongari Bagtzoglou, A" sort="Dongari Bagtzoglou, A" uniqKey="Dongari Bagtzoglou A" first="A." last="Dongari-Bagtzoglou">A. Dongari-Bagtzoglou</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Periodontology, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, 263 Farmington Ave</s1><s2>Farmington, CT 06030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of dental research</title><title level="j" type="abbreviated">J. dent. res.</title><idno type="ISSN">0022-0345</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of dental research</title><title level="j" type="abbreviated">J. dent. res.</title><idno type="ISSN">0022-0345</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chronic kidney disease</term><term>Epidemiology</term><term>Inflammation</term><term>Periodontitis</term><term>Predictive factor</term><term>Protein</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parodontite</term><term>Néphropathie chronique</term><term>Facteur prédictif</term><term>Protéine</term><term>Epidémiologie</term><term>Inflammation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) ≥ 5 mm and (CAL) ≥ 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. CKD was defined based on eGFR < 60 mL/min/1.73m<sup>2</sup> and albuminuria > 30 mg/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Loannidou, E" sort="Loannidou, E" uniqKey="Loannidou E" first="E." last="Loannidou">E. Loannidou</name></region><name sortKey="Dongari Bagtzoglou, A" sort="Dongari Bagtzoglou, A" uniqKey="Dongari Bagtzoglou A" first="A." last="Dongari-Bagtzoglou">A. Dongari-Bagtzoglou</name><name sortKey="Swede, H" sort="Swede, H" uniqKey="Swede H" first="H." last="Swede">H. Swede</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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